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Erectile Dysfunction Health Center

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New Inhaled Impotence Drug Shows Promise

Backers Say PT-141 Is Effective and Safe
WebMD Health News

Nov. 6, 2003 - A new type of erectile dysfunction drug that is delivered by nasal spray shows promise in early clinical trials. Instead of directly affecting blood vessels in the penis as the currently available drugs do, the novel treatment targets the brain -- specifically, the region of the brain that regulates sexual response.

In a Thursday morning news conference, officials with New Jersey manufacturer Palatin Technologies Inc. said they plan to study the treatment in men who either don't respond to or cannot take Viagra or similarly acting drugs for erectile dysfunction. They also plan to test it for sexual dysfunction in women and are searching for a corporate partner to help them develop and market the drug, now known as PT-141.

Few Side Effects at Low Doses

More trials of the drug in men with erectile dysfunction are scheduled for completion late in 2006, and the company hopes to win FDA approval within the following year. If that happens, PT-141 could be the first drug approved for erectile dysfunction that acts on the central nervous system.

Another central nervous system-acting drug, Uprima, was slated to become the first real competitor to Viagra until its manufacturer withdrew its application for FDA approval in the summer of 2000. According to news accounts, one in 30 men who took the optimal dosage of Uprima fainted or suffered severe low blood pressure as a result.

Urologist and impotence researcher Harin Padma-Nathan, MD, who led trials for both Uprima and PT-141, says low blood pressure was not seen as a side effect in the 271 men taking part in the newly reported PT-141 trial.

"It was very clear that (PT-141) was very different from any other centrally acting agent," he said Thursday.

He added that side effects with the lowest doses of PT-141 were very similar to what has been seen with Viagra, Levitra, and another drug expected to win approval for the treatment of erectile dysfunction called Cialis. All three drugs work by increasing blood flow to the penis, creating an erection.

PT-141 is in a new class of drugs that works on the part of the brain involved in sexual function.

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