Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier
WebMD

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine
WebMD

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion
    WebMD

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community
    WebMD

    Community

    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Erectile Dysfunction Health Center

Font Size
A
A
A

New Inhaled Impotence Drug Shows Promise

Backers Say PT-141 Is Effective and Safe

GI Problems Seen at Higher Doses

The men in the PT-141 trial who took the highest doses of the drug did have an unacceptably high incidence of gastrointestinal side effects, including nausea. They made up almost all of the roughly 12% of patients who dropped out of the trial, and one researcher says future studies will not include these higher doses.

Those included in the trial had mild to severe erectile dysfunction, and all had taken Viagra prior to enrollment and had responded well to it. The men took PT-141 via nose sprays at least three times, and some took it as many as 10 times before reporting improved erections.

One in 10 men who received placebo treatments reported restoration of normal erectile function, compared with roughly one in three patients treated with the lowest dosage of PT-141 and one in two patients treated with the highest dosage.

Palatin Technologies CEO Carl Spana, PhD, said men taking part in future studies will be started off at the lowest dosage and dosages will be increased gradually, if needed, to minimize side effects.

The company is also planning drug interaction studies evaluating the safety of PT-141 in men using nitrate medications for heart disease. Viagra and similar drugs are not recommended for these patients, and Spana says they account for roughly 10% of men with erectile dysfunction.

"We have no reason to expect that PT-141 will interact with nitrates," he says. "This represents a significant potential advantage."

San Francisco urologist Ira Sharlip, MD, who researches new impotence treatments but was not involved with the PT-141 study, tells WebMD that it is too soon to know whether the new drug will end up being an important new treatment.

"Right now in the United States we have Viagra and Levitra, and I expect that Cialis will soon be available," he says. "These are good drugs, but they aren't perfect. They don't work for everybody, so having a drug that works by a completely different mechanism of action is an attractive prospect."

1 | 2

Today on WebMD

handsome midadult man
11 tips to protect your erection.
man and woman on beach
How much do you know about ED?
 
stress in bed
Things that can deflate erections.
senior couple hugging
How medications work.
 
concerned man
Article
stress in bed
Slideshow
 
Life Cycle of a Penis
Article
Mens Body Problem
Slideshow
 
bored man
Article
Lamm Erections Over Life
Video
 
Food Men 10 Foods Boost Male Health
Article
senior couple hugging
Article
 

WebMD Special Sections