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Spider Venom for Erectile Dysfunction?
Sept. 24, 2009 -- The venom of a Brazilian spider may inspire new drugs to treat erectile dysfunction.
Researchers reported that news in Chicago at the American Heart Association's 63rd High Blood Pressure Research Conference.
The spider is the Brazilian wandering spider (Phoneutria nigriventer). Bites from that spider are intensely painful and "can cause priapism, a potentially harmful and painful erection that can last for many hours and lead to impotence," states an American Heart Association news release.
Researchers from Brazil and the Medical College of Georgia purified a toxin from that spider's venom and tested it in rats and mice.
The researchers found that the toxin causes a chemical chain reaction that sets the stage for better blood flow in penile tissue -- and that could help treat ED.
"This toxin could be important for development of new agents for treatment of ED," write the researchers, who included Kenia Nunes, PhD, of the Medical College of Georgia in Augusta.
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Indication
Uroxatral® (alfuzosin HCl 10 mg extended-release tablets) is an alpha1-blocker for the treatment of the signs and symptoms of BPH.
Important Safety Information
Do not take UROXATRAL if you have liver problems or if you are taking antifungal drugs like ketoconazole or itraconazole, or HIV drugs like ritonavir.
UROXATRAL can cause a sudden drop in blood pressure, especially when starting treatment. This may lead to fainting, dizziness, and lightheadedness. Do not drive, operate machinery, or do any dangerous activity until you know how UROXATRAL will affect you. This is especially important if you already have a problem with low blood pressure or take medicines to treat high blood pressure. There may be an increased risk of low blood pressure and fainting when taking UROXATRAL in combination with blood pressure medication or nitrates, or erectile dysfunction medication.
If considering cataract surgery (clouding of the eyes), tell your eye surgeon that you are currently taking UROXATRAL or have previously been treated with an alpha-blocker.
Before taking UROXATRAL, tell your doctor if you have kidney problems.
Also, tell your doctor if you or any family member(s) have or take medications for a rare heart condition known as congenital prolongation of the QT interval.
BPH and prostate cancer can cause the same symptoms. However, UROXATRAL is not a treatment for prostate cancer.
The most common side effects with UROXATRAL are dizziness, upper respiratory tract infection, headache, and tiredness.
Please see UROXATRAL full prescribing information.
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