Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Eye Health Center

Font Size

Juvenile Macular Degeneration: Stargardt's and Best Disease

Stargardt Disease continued...

Stargardt disease does not cause a loss of peripheral, or side, vision. Most people don't lose night vision, but may have trouble adjusting between dark and light environments. Color vision is also affected in later stages of the disease.

Genetics of Stargardt disease. Researchers have identified a specific gene that they believe causes Stargardt disease. If both parents carry one mutated gene and one normal gene, their children have a 25% chance of developing the disease. People who inherit only one mutated gene don't develop the disease. However, they can pass on the disease without knowing it.

Best Disease

The second most common type of JMD is called Best disease, or Best vitelliform macular dystrophy. It was discovered in 1905 by Friedrich Best, a German ophthalmologist. The disease can be detected between ages 3 and 15 years old, although symptoms may not develop until later.

Signs of Best disease. Best disease appears as a bright yellow fluid-filled sac, or cyst, under the macula. The cyst looks like a sunny-side-up egg. Vision may be normal or near normal at this stage. Eventually the sac bursts, and the fluid spreads throughout the macula.

Best disease symptoms. The disease occurs in stages over a period of years. In early stages, there is no loss of vision. During later stages, the disease causes central vision loss in one or both eyes. Symptoms include blurred and distorted vision. Central vision may deteriorate to about 20/100 in later stages. Some people with Best disease never progress to later stages and may not have serious vision loss. Others may lose vision in one eye, but not the other.

Genetics of Best disease. If one parent has Best disease and one does not, there is still a 50% chance that their children will inherit the disease. Children who do not develop the disease can't pass it on to their children.

Juvenile Retinoschisis

Juvenile retinoschisis, also called X-linked retinoschisis, occurs primarily in young males. Vision loss tends to occur between age 10 and 20 and then remains stable until age 50 to 60.

Today on WebMD

Woman holding tissue to reddened eye
Learn about causes, symptoms, and treatments.
Simple annoyance or the sign of a problem?
red eyes
Symptoms, triggers, and treatments.
blue eye with contact lens
Tips for wearing and caring.
Understanding Stye
human eye
eye exam timing
vision test
is vision correction surgery for you
high tech contacts
eye drop