Macular Degeneration Drug Adds Vision
Lucentis Prevents Vision Loss, Restores Vision for Many
WebMD News Archive
Oct. 4, 2006 -- Lucentis, a newly approved drug for age-related macular
degeneration, not only prevents blindness but actually improves many patients'
Macular degeneration is the leading cause of blindness in people aged 50 and
older. The major finding comes from two clinical trials reported in the Oct. 5
issue of The New England Journal of Medicine.
David M. Brown, MD, a retina surgeon at Houston's Methodist Hospital, was a
researcher for one study. Philip J. Rosenfeld MD, PhD, of the University of
Miami's Bascom Palmer Eye Institute, was a researcher for the other.
"It is truly better than our greatest expectations," Brown tells
WebMD. "The biggest advance from both trials is they are the first ever to
show significant improvement in vision."
"This is not a cure," Rosenfeld tells WebMD. "If macular
degeneration patients have lost vision for a year or longer, this is not going
to restore their vision. But for the right patients, at the right point in
their disease, these drugs are extremely beneficial."
Lucentis is expensive. The wholesale cost is $2,000 a dose. But Brown says
there are different ways to look at this cost.
"I have a patient, a farmer with one eye, who was 96 when he started the
study and is 99 now -- still driving his tractor and still taking care of his
cows," Brown says. "They talk about the cost of this drug. But the cost
of not being able to drive and losing your job and being put in assisted living
-- that is the true cost."
Lucentis and Avastin
While the Brown and Rosenfeld studies focused on Lucentis, they have
implications for a drug that wasn't being tested: Avastin.
Lucentis, made by Genentech, is an offshoot of Avastin, a cancerdrug also
made by Genentech. Lucentis is 100 times more expensive than Avastin.
Lucentis and Avastin work by exactly the same mechanism. Both are
antibody-based drugs that block the chemical messenger -- vascular endothelial
growth factor A or VEGF-A -- that tells new blood vessels to grow.
In cancer, Avastin keeps tumors from growing the blood vessels they need to
survive. In wet macular degeneration, Lucentis stops the
inappropriate growth of blood vessels that leak fluid and displace the