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Fibromyalgia Health Center

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Lyrica for Fibromyalgia Treatment

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Side Effects of Lyrica

Side effects appear related to how much Lyrica you take. That means the higher your dose of Lyrica, the more likely you may be to have side effects.

The most common side effects are:

Other common side effects include:

Lyrica may also make it hard to concentrate and pay attention, which can make driving dangerous. Ask your doctor if it is OK to drive when taking this medicine. You should not drive or operate machinery until you know how the drug affects you.

In rare cases, severe allergic reactions occur. Seek immediate medical help if you have:

  • Breathing trouble
  • Hives
  • Swelling of the face, mouth, gums, lips, tongue, or neck

Before You Take Lyrica

Always make sure your doctor knows about all the other medications you are taking. This includes over-the-counter drugs, as well as herbs and supplements. Some prescription medicines may interact with Lyrica and may lead to dangerous side effects. Such drugs include:

  • Blood pressure medicines called ACE inhibitors; taking Lyrica with these medicines increases your chance for swelling and hives.
  • Diabetes medicines Avandia (rosiglitazone) or Actos (pioglitazone); if you take these drugs with Lyrica, you may have a higher risk for swelling or weight gain.
  • Narcotic pain medicines (such as oxycodone), anxiety medicines (such as lorazepam), and tranquilizers; combining these drugs with Lyrica increases your chances for dizziness and sleepiness.
  • Sleep medicines make you nod off, and Lyrica can cause drowsiness. Combining the two can be dangerous.

Do not drink alcohol when on Lyrica. Doing so can increase Lyrica's side effects and make you dangerously sleepy.

Also tell your doctor if you have any other medical conditions, including:

  • Bleeding disorders or low platelet counts
  • Heart problems
  • Kidney problems or if you receive kidney dialysis (a lower dose of Lyrica is needed if you have kidney problems)

Women who are breastfeeding, pregnant, or planning to become pregnant, should talk to their doctor about whether Lyrica is right for them. Researchers do not know if Lyrica is safe to take during pregnancy, or if it passes into breast milk.

WebMD Medical Reference

Reviewed by David Zelman, MD on May 26, 2014
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