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Dec. 6, 2012 -- Popping a painkiller such as ibuprofen to ward off exercise pain or anticipated pain is a common practice among athletes of many ability levels.

Some think it will also improve performance as it reduces pain.

But the practice may be hazardous, according to new research that focused on the use of the anti-inflammatory drug ibuprofen before and after workouts.

"We conclude that nonsteroidal anti-inflammatory drug (NSAIDs) consumption by athletes is not harmless and should be discouraged," writes Kim van Wijck, MD, a surgical resident at ORBIS Medical Center, Maastricht, the Netherlands.

She found ibuprofen aggravated exercise-induced injury in the small intestine in healthy, trained men who were used to endurance workouts. "We used only two oral doses of ibuprofen, in the evening and in the morning before the exercise, and did see small intestinal cellular damage," she says.

"This damage was fully reversible approximately one hour after cessation of the exercise bout," van Wijck says.

She worries, however, about long-term use and its effects.

The study is published in the December issue of Medicine & Science in Sports & Exercise.

Painkillers Before Exercise: Study Details

For the study, van Wijck evaluated nine healthy, trained men. On average, they were age 27.

They typically spent three to 10 hours weekly in endurance sports. She assessed them on four occasions to look at the effect of ibuprofen (Advil, Motrin). In four sessions, they:

  • Took 400 milligrams of ibuprofen twice before cycling an hour
  • Cycled an hour without taking ibuprofen
  • Took 400 mg of ibuprofen twice while at rest
  • Rested without taking ibuprofen

In previous research, van Wijck showed that exercise reduces blood flow in the gastrointestinal system. It is also known that NSAIDs like ibuprofen can reduce blood flow.

In the new study, she evaluated indicators of intestinal injury after each of the four sessions. Both ibuprofen and cycling resulted in higher levels of these indicators. Levels were higher after cycling with ibuprofen than after any of the other three conditions.

The combination of ibuprofen and exercise also decreased what experts call ''gut barrier function," possibly resulting in bacteria escaping from the intestines into the blood.

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