April 3, 2000 -- (Great Falls, Mont.) -- A mammogram revealed a small
cancerous tumor in Opal Addison's breast, and she opted for a lumpectomy. When
her oncologist recommended that she enroll in a clinical trial of an
experimental drug to prevent further cancer, Addison (not her real name)
readily agreed. She did it to help herself and possibly others. ''If I was 21,
I probably wouldn't do it,'' says the 70-year-old Illinois woman. ''But now, if
I can help anybody, I'm glad to.''
Now completing the first year of the five-year study, she takes a daily
pill, visits her doctor for blood tests every three months, and has a mammogram
every six. So far, she's been free of side effects such as nausea or night
sweats, which she says would have to be ''pretty severe before I would drop
Those first strands of gray hair are a sign of the inevitable. We’re getting older and our bodies are changing. We may grow a little rounder around the waistline, or wake in the night, or feel a little stiffer in the morning. Yet while we adapt to new realities, we shouldn’t discount every symptom as just further evidence of aging.
How do you know when to ignore your body’s lapses or when to seek medical advice? What’s normal aging, and what’s not?
“Aging, in and of itself, is a subtle, quiet process,”...
Older volunteers can help increase overall knowledge about the effectiveness
of cancer drugs. But patients older than 65 are woefully underrepresented in
cancer treatment trials, according to a study published in the December 30,
1999 issue of the New England Journal of Medicine.
The Scope of the Problem
Oncologist Laura Hutchins, M.D., of the University of Arkansas for Medical
Sciences in Little Rock, led the study that looked at 16,396 patients enrolled
in 164 cancer treatment trials. Only 25% were older than 65, even though 63% of
all cancer patients are in that group. When it comes to breast cancer in
particular, only 9% of the patients in clinical trials were past 65 -- though
half of all cancer cases occur in women that age and older.
Complicating the issue, health experts predict a "pandemic'' of cancer
as baby boomers age. ''When that happens, we're going to be totally unprepared
for dealing with cancer in the elderly," says medical oncologist Charles
Coltman, MD, of the University of Texas Health Science Center in San Antonio,
and another study co-author.
It's not enough, experts say, to study cancer treatment drugs in the young.
Aging immune systems and organs affect the way drugs are absorbed and
eliminated. Many elderly patients already take medications for diseases such as
high blood pressure that could interfere with the needed new treatments. And
sometimes cancers run a different course in elderly patients.