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    Why Older People Are Forgetful

    Brain Tissue Changes May Play a Role in Forgetfulness, Researchers Say
    WebMD Health News
    Reviewed by Laura J. Martin, MD

    Sept. 15, 2010 -- Abnormal brain tissue changes called brain lesions may be more at fault than previously thought in forgetfulness in older people, new research shows.

    Scientists at Rush University Medical Center in Chicago say the same brain lesions that are associated with dementia in old age may be responsible for mild memory loss.

    The researchers studied 350 Catholic nuns, priests, and brothers who were given memory tests annually for up to 13 years, and after death, had their brains examined for lesions.

    The study found that memory decline tended to be gradual before speeding up in the last four or five years of life.

    Tangles and Lewy Bodies

    Researchers say they found that strokes as well as protein accumulations called tangles and Lewy bodies seemed to be related to memory loss in older people.

    They report that minimal gradual memory declines were seen in the absence of tangles, while Lewy bodies and strokes doubled the rate of gradual memory loss.

    Tangles and Lewy bodies were found to be associated with rapid memory decline but explained only about a third of the memory loss.

    “It appears these brain lesions have a much greater impact on memory function in old age than we previously thought,” study author Robert S. Wilson, PhD, of the Rush University Medical Center, says in a news release. “Our results challenge the concept of normal memory aging and hint at the possibility that these lesions play a role in virtually all late-life memory loss.”

    The Study

    The subjects, for up to 13 years, had memory tests that involved word recall, naming, verbal, number, and reading assignments, and all had agreed to autopsies so that their brains could be studied.

    “Understanding how and when these brain lesions affect memory as we age will likely be critical to efforts to develop treatments that delay memory loss in old age,” Wilson says.

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