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    Should You Take Daily Aspirin for Your Heart?

    Take the Right Amount continued...

    The drug also affects the hormone-like prostaglandins in your stomach, which help protect your stomach lining from damage. When you take aspirin daily, it can strip them away and that makes your stomach more likely to bleed.

    Taking higher doses, like 325 mg, increases the risk of bleeding and stomach side effects, says Orly Vardeny, PharmD, an associate professor at the University of Wisconsin-Madison School of Pharmacy. “For that reason, we stick with 81 mg, because we know it works, and it's less likely to cause some of these side effects.”

    Some aspirin tablets have a coating that lets them break down in your small intestine, rather than the stomach. If you get an upset tummy from the drug, coated tablets may be helpful. But they won't reduce your chances of stomach bleeding.

    Some Pain Medicines Don’t Mix

    Aspirin is in a class of drugs known as NSAIDs. These pain meds are good for easing inflammation in your body, but they also make stomach bleeding more likely.

    More than 100,000 people who take NSAIDs (including aspirin) are hospitalized for this serious problem every year. Of all the people who have stomach bleeding due to NSAIDs, 40% take low-dose aspirin daily, Cryer says.

    You're more likely to have the problem if you take more than one type of NSAID. “When you take aspirin along with a pain medicine of the same class, like ibuprofen, you increase your risk of having a bleed by six-fold,” Cryer says.

    If you have long-term pain, ask your doctor what drug to take with daily aspirin. He may prescribe you something or suggest over-the-counter acetaminophen. It's not an NSAID.

    “For pain relief, especially in older adults that may have things like arthritis, the safest option for pain relief is acetaminophen,” Vardeny says, “because it doesn't have the same risk for stomach effects and bleeding.”

    If your doctor wants you to take another NSAID along with your daily aspirin, he may also prescribe a drug called a proton-pump inhibitor, which works in your stomach to lower the odds of bleeding.

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