2/3 of Heart Failure Patients Don't Get Major Drug
Aldosterone Antagonists Improve Heart Failure Survival, but Only 1 in 3 Get Them
WebMD News Archive
Oct. 20, 2009 -- More than two-thirds of patients hospitalized with serious
heart failure aren't prescribed an aldosterone antagonist, a recommended
therapy that increases the odds of survival.
Aldosterone is a hormone that is released in the setting of heart failure.
It causes salt and water retention, which can lead to worsening symptoms (such
as shortness of breath and leg swelling). Aldosterone antagonists block the
action of aldosterone and are a well-recognized part of heart failure
Published guidelines specifically recommend aldosterone antagonists for
patients with moderate-to-severe heart failure. Aldactone and Inspira are the
two aldosterone antagonists (AAs) available on the market. They’re not for
every patient. But the present study shows that far too many patients who
should be getting AAs are not.
The finding comes from a survey by Cleveland Clinic researcher Nancy M.
Albert, PhD, RN, and colleagues, who followed up on 43,625 AA-eligible heart
failure patients released from 241 U.S. hospitals from 2005 through 2007.
"Less than one-third of eligible patients hospitalized for heart failure ...
received heart failure guideline-recommended aldosterone antagonist therapy,"
Albert and colleagues write in the study.
What's going on?
Old guidelines, in effect during the study period and only updated in 2009,
said the treatment "should be considered" rather than saying it "is
Also, in some published studies there "may have been an overestimation of
harm" because of the drug's potential to negatively affect kidney function,
Albert and colleagues suggest.
Another problem is that AAs are well-known diuretics (water pills), which
may have confused some doctors as to their more extensive mechanism of action
in heart failure.
And it is possible that institution of AA therapy did not occur until
patients’ other medications had been optimized in the outpatient setting.
But failure to adhere to recommended treatment algorithms by physicians may
be a major reason for low rates of AA therapy. A recent survey of European
doctors showed the three main reasons they did not adhere to treatment
guidelines were patient compliance, long and complexly written treatment
guidelines, and time needed to get patients on all the recommended
"Given the substantial morbidity and mortality risk faced by patients
hospitalized with heart failure and the established efficacy of aldosterone
antagonist prescription in heart failure, a stronger uptake of [AA] therapy may
be warranted," Albert and colleagues conclude.
The findings appear in the Oct. 21 issue of the Journal of the American