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    Pill Cuts Risk of Death in Heart Failure Patients

    Procoralan Also Reduced Hospital Stays for Patients With Severe Heart Failure

    Procoralan Produces Benefits in 3 Months continued...

    Participants were given Procoralan or placebo on top of beta-blocker medication, the standard treatment for chronic heart failure.

    Fewer serious side effects occurred in patients getting Procoralan. However, they were more likely to develop a condition known as bradycardia, characterized by a dangerously slow heart rate: 5% vs. 1% in the placebo group.

    Adding Procoralan produced benefits within just three months and continued throughout the trial, Komajda says.

    The trial was considered a big win by the researchers, as the drug failed to reduce heart attacks, hospitalizations, or deaths in the BEAUTIFUL trial, which was reported at ESC in 2008.

    Procoralan fastens to the part of the electrical system that causes the heart to contract, slowing the heart rate, he says. It's the first drug to work by specifically slowing the heart rate.

    The study was funded by Servier, which makes Procoralan.

    Caution Urged

    In a commentary in the Lancet, John R. Teerlink, MD, of the University of California San Francisco, writes that much more work is needed before any firm conclusions can be drawn.

    Less than 25% of patients were getting the recommended dose of standard beta-blocker therapy, he says. And although all patients in the trial potentially qualified for implantable medical devices like defibrillators to shock a stopped heart back into rhythm, less than 3% percent had them, Teerlink writes.

    Procoralan "might reduce heart failure hospitalizations when added to contemporary heart failure therapies. However, whether [it] can improve outcomes in addition to optimally managed heart failure therapies or its benefits relative to other therapies, especially beta blockers, remains unknown," he writes.

    Jessup agrees further work is needed. "But if a patient can't tolerate beta-blockers or beta-blockers fail to get the heart rate down, this might prove to be an important addition to their treatment," she says.

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