Experimental Heart Failure Treatment Shows Promise
But experts caution that larger studies of combined treatment are needed
WebMD News Archive
By Amy Norton
TUESDAY, April 16 (HealthDay News) -- People with chronic heart failure might benefit from a combination of "shock waves" to the heart and an infusion of their own bone marrow cells, an early study suggests.
The therapy is still experimental, and experts said much more work is needed. But they also said the results, reported in the April 17 issue of the Journal of the American Medical Association, are promising.
The study, which included about 100 patients, added a new twist to a therapy heart disease researchers have been trying for about a decade -- using immature cells from patients' own bone marrow to try to aid damaged heart muscle.
There has been some success in helping recent heart attack sufferers. Overall, research suggests the cell therapy can cut the risk of a repeat heart attack, and even prolong people's lives.
But it has not worked as well for chronic heart failure -- where the heart's pumping ability declines over time, causing fatigue, breathlessness and fluid build-up in the legs. In the United States, close to 6 million adults have heart failure, often developing it after a heart attack first damages the heart muscle.
One theory on the limited results for heart failure is that patients' bone marrow cells are not retained in the heart for a long enough time.
So in the new study, German researchers first "pre-treated" patients with so-called shock wave therapy, which applies high-dose ultrasound to the chest. For patients, the experience is similar to having a diagnostic ultrasound of the heart, said senior researcher Dr. Andreas Zeiher, of Goethe University in Frankfurt.
One day after the shock wave therapy, patients' hearts were infused with a dose of their own bone marrow cells.
The idea, Zeiher explained, is that the shock waves might spur the heart to churn out chemicals that attract more bone marrow cells to the damaged portion of heart muscle.
After four months, his team found, there was a 3 percent increase in the patients' left ventricular ejection fraction -- the percentage of blood pushed out of the heart with each contraction.
That's a "decent" improvement, said Dr. Eduardo Marban, director of the Cedars-Sinai Heart Institute in Los Angeles. And it's possible it could translate into long-term benefits -- like a lower risk of a repeat heart attack or longer life, according to Marban.
But, he said, larger studies are needed to prove that.
"This is a feasibility and efficacy study," Marban explained. He added that neither shock waves nor bone marrow cells are approved treatments for heart failure. "You're not going to be able to go to your doctor and ask for this."
Dr. Gregg Fonarow, a professor of cardiovascular medicine and science at the University of California, Los Angeles, agreed that caution is in order.