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    Heart Failure Therapy Benefits Women More Than Men?

    But study finds they're less likely than males to receive pacemaker that synchronizes heartbeats

    WebMD News from HealthDay

    By Dennis Thompson

    HealthDay Reporter

    MONDAY, June 23, 2014 (HealthDay News) -- Women suffering from heart failure derive more benefit than men do from a pacemaker treatment. But they are less likely than men to receive it, a new analysis shows.

    Cardiac resynchronization therapy (CRT) -- which uses a pacemaker to improve the coordination of heartbeats -- led to a 60 percent reduction in women's risk of heart failure or death, researchers from the U.S. Food and Drug Administration report. The therapy reduced their risk of death alone by 55 percent.

    Those benefits far outstripped rates of effectiveness for men, whose risk of heart failure or death declined by only 26 percent with CRT, and their risk of death alone by 15 percent, the study authors said.

    Despite this, fewer women than men are treated with CRT, in part because treatment guidelines are based on clinical trials that included too few women, said senior study author Dr. David Strauss, a medical officer at the FDA Center for Devices and Radiological Health.

    "Women were underrepresented in the individual clinical trials for CRT," Strauss said, noting that only about one-fifth of the patients in those trials were female. "By combining data from multiple clinical trials, we were able to better identify which specific women were most likely to benefit from CRT."

    These findings could shake up the way patients are chosen for the therapy, with separate guidelines set for men and women, said Dr. Gordon Tomaselli, director of cardiology at Johns Hopkins School of Medicine and past president of the American Heart Association.

    "Heart disease in women and in men is different," Tomaselli said. "Women shouldn't be excluded from having these devices, and the parameters for where there should be some benefit should be different for women than in men."

    CRT helps treat an electrical disorder of the heart that causes one side of the heart to beat before the other, Strauss said. A special type of pacemaker has been designed that corrects the electrical signal and resynchronizes the person's heartbeat.

    The FDA decided to take a closer look at the clinical trial data following studies that suggested women might derive more benefit from CRT than men, the study authors said in background information.

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