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Miscarriages Linked to Heart Disease

Factors That Cause Early Pregnancy Loss Could Also Cause Cardiovascular Problems
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Feb. 20, 2003 -- Women who have a history of miscarriages early in pregnancy may be at increased risk for heart disease. A new study from the U.K. is the latest to suggest a direct link between certain complications of pregnancy and cardiovascular problems that occur later in life.

Cambridge University researchers found that women who had experienced one miscarriage prior to the birth of their first child had about a 50% increased risk of developing heart disease. Those with three or more pregnancy losses were almost two-and-a-half times the risk of women who had never miscarried. The study appears in the latest issue of the British Medical Journal.

In earlier work, lead researcher Gordon Smith, MD, PhD, and colleagues reported a strong association between complications of late pregnancy and subsequent risk of heart disease. They found that having a low birth weight baby, giving birth preterm, and giving birth with a diagnosis of preeclampsia were each associated with a doubled risk of developing heart disease within the next 15 to 20 years. Women with all three conditions had a sevenfold increase in risk.

"We hypothesized that the same association might be seen in women who have early pregnancy losses," Smith tells WebMD. "We aren't suggesting that they already have heart damage and that is why the pregnancies go wrong. Rather, we believe the same factors that give rise to pregnancy complications are also promoting the development of heart disease."

In their latest study, the research team analyzed national data on births in Scotland between 1981 and 1985, as well as deaths and hospital admissions due to ischemic heart disease between 1981 and 1999. After adjusting for other known heart disease risk factors, such as high blood pressure and the mother's age, the researchers found that women with three or more early pregnancy losses were more than twice as likely to develop heart disease as women who had never had a miscarriage.

Smith tells WebMD that a group of blood clotting conditions called thrombophilias, which is believed to play a part in many miscarriages, could explain the link between pregnancy complications and heart disease. Thrombophilias may be inherited or acquired and are thought to interfere with embryo implantation and the development of the placenta.

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