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    Drug for Chest Pain May Promote Vessel Damage

    Nitroglycerin Use Linked to Production of Free Radicals
    WebMD Health News

    Feb. 6, 2004 - It has been well over a century since doctors learned that nitroglycerin was useful for relieving the crushing chest pain known as angina that often occurs with coronary artery disease. The treatment is still widely used today, but a new study suggests it may ultimately hurt heart patients more than it helps them.

    Researchers say long-term nitroglycerin use appears to promote the production of unstable molecules known as free radicals, which have been implicated in the advancement of heart disease. The concern is that the drug's pain relieving benefit comes at the price of making the patient's heart condition worse.

    "This is a drug that has been around forever, and it has just been assumed to be safe," Duke University professor of medicine Jonathan Stamler, MD, tells WebMD. "Our findings and those of others suggest a real need to take a fresh look at it."

    Drug Tolerance

    Nitroglycerin relieves chest pain by opening constricted blood vessels, allowing more oxygen-rich blood to flow to the heart. But patients quickly build up tolerance to the drug if used for long periods of time.

    It was their efforts to identify the cause of this tolerance that led Stamler and colleagues to conclude that the drug may promote blood vessel damage. Two years ago, the research team identified a compound that holds the key to the drug's ability to dilate blood vessels and relieve chest pain. The compound resides in a part of the cell known as the mitochondria.

    In lab studies, they found that exposure to high doses of nitroglycerin not only decreased the activity of this compound, but it also damaged the mitochondria. This, in turn, resulted in the increased production of free radicals -- unstable molecules that can damage heart cells and blood vessel walls. The findings are published in the February issue of The Journal of Clinical Investigation.

    "Typically when people become tolerant to this drug, the response is to push the dosage higher," Stamler says. "But if we now understand that this tolerance is associated with the production of the same free radicals that have been implicated in cardiovascular disease, this strategy does not make sense."

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