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    Drug-Coated Stents Safest for Whom?

    Study: Drug-Eluting Stents May Safely Trump Bare Metal Stents in Certain Patients
    WebMD Health News
    Reviewed by Louise Chang, MD

    Oct. 3, 2007 -- The safety of drug-coated stents is back in the news, and this time, the findings favor drug-coated stents -- at least, for some patients.

    A new study shows that patients who are the most likely to need follow-up procedures after getting stents may have the best risk-benefit profile for drug-coated stents.

    "This is good news, reassuring patients and cardiologists about the safety of drug-eluting stents when used in appropriate individuals," researcher Jack Tu, MD, PhD, says in a news release.

    Tu works in Toronto at the Institute for Clinical Evaluative Sciences and the University of Toronto. His study appears in tomorrow's edition of The New England Journal of Medicine.

    Confused about stents? Take a minute to get up to speed with the following stent facts.

    Stents 101

    Stents are tiny metal mesh tubes that are inserted to hold open blocked or narrowed coronary arteries.

    The coronary arteries supply blood to heart muscle. If the coronary arteries narrow, a heart attack becomes more likely.

    Some stents are made of bare metal. Other stents are coated with drugs that help prevent the stents from clogging up.

    Recent research has raised safety concerns about drug-coated stents (also called drug-eluting stents) and the risk of blood clots, heart attacks, and death. The debate about that risk is ongoing.

    Stent Study

    The new stent study is based on more than 7,400 Canadians who received stents between December 2003 and March 2005.

    Half of the patients received bare-metal stents. The other half received drug-coated stents.

    The patients and their doctors made the decision about what type of stent to get. They weren't assigned to get a certain type of stent.

    All of the patients took a blood-thinning drug for a year after getting their stents.

    Tu's team followed the patients for up to three years.

    Stent Survival

    The patients who got drug-coated stents had a better survival rate than those who got the bare-metal stents.

    During the three-year study, 5.5% of patients in the drug-coated stent group died of any cause, compared with 7.8% of those who got bare-metal stents.

    The heart attack rate in the two years following stenting was similar for both groups (5.2% of patients who got bare metal stents and 5.7% of those who got drug-coated stents).

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