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Heart Disease Health Center

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Drug-Coated Stent Fit for the Long Haul?

'Xience' Stent Strong in 1-Year Study, but Some Experts Want to Wait for Long-Term Results
WebMD Health News

April 22, 2008 -- The new Xience stent beat the popular Taxus stent in a one-year trial, but experts disagree on whether stent science is moving too fast.

Stents prop open arteries that have been unclogged by balloon angioplasty. Bare-metal stents tend to reclog more often than drug-coated stents. Doctors were very quick to start using drug-coated stents, even in patients with far more complex heart disease than the patients in whom the devices were tested.

Recently, doctors were blindsided by the discovery that blood clots can form at the site of drug-coated stents long after implantation. This led to significant confusion, which is only just now settling down as doctors better learn how to prevent these clots.

Now Xience, a new stent with a new kind of drug coating, seems safer and more effective in a one-year clinical trial. Should the FDA approve it? Or should history make the FDA wait until more is known?

Manesh Patel, MD, assistant professor of cardiology at Duke University, argues for caution.

"We want a durable result with the device we use. That is the conundrum in a rapidly moving science," Patel tells WebMD. "We have new devices that may be safer and more effective, but we need time to see how well they reduce long-term events."

Gregg W. Stone, MD, director of cardiovascular research and education at the New York Presbyterian Hospital/Columbia University's Center for Interventional Vascular Therapy, led the 1,002-patient study of the new stent.

Stone says it's already known that drug-coated stents -- doctors call them drug-eluting stents -- work better than bare-metal stents in most cases. Yet two-thirds of the time, he says, they are used in patients who have more complex heart disease than the patients for whom the stents are officially approved.

"Physicians have to use their judgment, based on what they know and on the studies that have been done, to decide whether the use of a drug-eluting stent is in the individual patient's best interest," Stone tells WebMD. "I don't think this new stent is going to markedly change how doctors use stents. It will just convert doctors who have used earlier stents to this one because the outcomes look safer and more effective."

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