Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Heart Disease Health Center

Font Size

Genetic Tests Check Risk for Sudden Death

Study Shows Genetic Tests Are Cost-Effective Way to Measure Risk for Surviving Relatives
WebMD Health News
Reviewed by Louise Chang, MD

Nov. 16, 2009 (Orlando, Fla.) -- If you have a relative who suffered sudden unexplained death, postmortem genetic testing is a cost-effective way of identifying mutations that may place you and other surviving family members at increased risk for potentially fatal heart rhythm disturbances, a new study suggests.

"Postmortem gene testing may be a better way to determine risk to relatives than traditional comprehensive cardiac testing of first-degree relatives," says researcher Michael J. Ackerman, MD, PhD, of the Mayo Clinic in Rochester, Minn.

Nearly 300,000 Americans a year suffer sudden cardiac death, in which a person dies within minutes after an abrupt loss of heart function.

Genetic defects explain up to 25% to 30% of these cases, Ackerman says. But rather than provide genetic testing to the deceased individual, the recommended approach is to offer comprehensive cardiac testing to first-degree relatives, he says.

For the study, Ackerman and colleagues performed postmortem testing for two genetic heart rhythm disorders associated with sudden cardiac death on 146 people who had suffered sudden unexplained deaths. Results showed that 40 patients (27%) had one of the two mutations known to cause sudden cardiac death.

The researchers then performed further testing on 160 relatives of victims who tested positive for mutations. The tests included genetic screening and either treadmill stress tests or electrocardiograms.

The total cost of the gene-directed exams: $6.78 million.

Then, the researchers performed the currently recommended comprehensive cardiac testing on all relatives of the sudden unexplained death victims, regardless of their mutation status. The cost exceeded $7.7 million.

“Use of a [genetic] autopsy to direct further testing would save almost $1 million dollars," Ackerman says.

A major obstacle to genetic testing is that insurance companies typically don't cover the cost, while they do pay for the more expensive comprehensive cardiac testing for all family members, he says.

Johns Hopkins cardiologist Gordon Tomaselli, MD, who moderated a news briefing on the findings, tells WebMD that he hopes data like these will propel more insurance companies to pay for the gene testing.

The study was reported at the annual meeting of the American Heart Association.

Today on WebMD

x-ray of human heart
A visual guide.
atrial fibrillation
Symptoms and causes.
heart rate graph
10 things to never do.
heart rate
Get the facts.
empty football helmet
red wine
eating blueberries
Simple Steps to Lower Cholesterol
Inside A Heart Attack
Omega 3 Sources
Salt Shockers
lowering blood pressure