Early HRT Doesn't Reduce Heart Risk
Starting Hormone Therapy Around Menopause Offers No Decrease in Risk of Heart Disease
WebMD News Archive
Is Today’s Hormone Therapy Safer?
Hormone therapy researcher JoAnn Manson, MD, who was a principal
investigator for the WHI trial, tells WebMD that women taking hormone
treatments today for menopausal symptoms may have a lower risk for
treatment-related side effects than the women in the original trial.
That’s because the women who participated in the WHI intervention trial were
taking much higher doses of estrogen than women typically take today and they
took them for longer periods.
It is generally believed, but has not been proven in clinical studies, that
the lower-dose hormone formulations widely used today are safer than the
higher-dose formulations used a decade ago.
Many women now use a low-dose hormone patch, which has been shown to have a
lower risk for blood clots.
“There is always a trade-off when you take any drug,” says Manson, who is
chief of the division of preventive medicine at Boston’s Brigham and Women’s
Hospital. “But it is important to point out that heart disease is not common in
women around the time of menopause. Their risk is very low.”
Manson agrees with the current recommendation that women experiencing
troubling menopausal symptoms take hormones in the lowest effective doses for
the shortest duration possible.
She says most women should be able to discontinue treatment within two to
North American Menopause Society Director Margery Gass, MD, says women with
mild to moderate symptoms may find the relief they need with lifestyle
modification and natural remedies.
For reducing hot flashes, she recommends getting plenty of exercise,
dressing in layered clothing, using fans and air conditioning when needed, and
avoiding spicy foods, alcohol or caffeine.
“These things do work for many women,” she says.