Waiting to Fill Blood Thinner Prescription Dangerous
Stent Patients Who Wait to Fill Blood Thinner Prescription Double Their Risk of Heart Attack, Death, Study Finds
WebMD News Archive
April 20, 2010 -- Waiting even one day to fill a prescription for blood
thinners after heart stent surgery may prove risky.
A new study shows that heart stent patients who waited a day or more to fill
their prescription for Plavix, a blood thinner medication, were twice as likely
to suffer a heart attack or death in the months following the procedure.
A stent is a small metal tube that is surgically implanted to prop open a
clogged artery and reduce the risk of heart attack. After insertion of the
stent, blood thinners are typically prescribed to prevent the artery from
Researchers found one in six heart stent patients did not fill their
prescription for blood thinner medication on the same day they were discharged
from the hospital, as recommended. The average delay was three days.
“A surprising number of patients delayed filling the prescription,”
researcher P. Michael Ho, MD, PhD, a cardiologist at the Denver Veterans
Administration Medical Center and associate professor of medicine at the
University of Colorado in Denver, says in a news release. “We expected their
physicians and the health care system to be more vigilant in making sure they
got their medications.”
Waiting a Day Risky
In the study, published in Circulation: Cardiovascular Quality and
Outcomes, researchers examined the health records of 7,402 people who had
heart stents implanted from 2004 to 2007 and were able to get prescription
drugs at reduced prices through their health plans.
The results showed 16.3% of heart stent patients waited at least a day to
fill their prescription for blood thinner medication and 2.2% never filled
it. Those who delayed filling the first prescription also delayed getting
subsequent refills of Plavix.
Over 22 months of follow-up, patients who waited a day or more to fill their
blood thinner medication prescription had a 14.2% risk of heart attack or
death, which was nearly double the 7.9% risk among those who filled their
prescription on the day they were discharged from the hospital. The
majority of excess events occurred within 30 days of discharge, underscoring
the importance of getting on (and staying on) the prescribed medications right
Researchers found that people who waited to fill their blood thinner
prescription were older and more likely to have other medical problems that
required additional prescriptions.
“When cardiac patients are discharged from the hospital, they are prescribed
a lot of medications and may not remember the importance of all of them,
specifically [Plavix],” Ho says. “In addition, the doctors in the hospital may
not know who is providing their patients follow-up care and often there is a
gap in the transfer of information from inpatient to outpatient settings. We
need to improve this transition period from hospital to home and make sure
patients understand the importance of their medications.”