Belly Fat Stem Cells May Help Heart
Study Shows Fat Stem Cells May Improve Heart Function After Heart Attack
Nov. 16, 2010 (Chicago) -- Stem cells taken from belly fat may be able to boost cardiac function after a heart attack, preliminary research suggests.
In a study of 14 people who had a heart attack, fat-derived stem cells reduced the amount of damaged heart tissue, increased blood flow in the heart, and improved the heart's pumping ability, compared with placebo.
Due to the study's small size, however, the difference between the two groups could have been due to chance.
"But given the dramatic and consistent results, we think it is a real effect," says study head Eric Duckers, MD, PhD, of Erasmus University Medical Center in Rotterdam, Netherlands.
U.S. stem cell researcher Douglas Losordo, MD, of the program in cardiovascular regenerative medicine at Northwestern Memorial Hospital in Chicago, tells WebMD, "The evidence strongly suggests fat stem cells can stimulate the repair process after a heart attack. But these are still early days. We have to await the results of larger randomized trials [pitting placebo against fat stem cells] to determine if the method improves quality of life and extends lives."
It's not the first time heart attack patients have been treated with stem cells. But previous studies used bone marrow stem cells, Duckers says. "The advantage of fat-derived cells is the ease with which you can get them."
"You don't get enough stem cells from bone marrow, so you have to culture them in the lab, a process that can take six to eight weeks," Duckers tells WebMD. He estimates that the 40 cubic centimeters of bone marrow typically removed yields about 25,000 stem cells.
In contrast, just 100 cubic centimeters of fat tissue -- about a half a coffee cup -- contains 2 million stem cells, he says. "With that many cells, you can isolate them and go straightway back to the patient."
How the Stem Cell Technique Works
In the study, the first of its kind, people were treated within 24 hours of their heart attack after undergoing cardiac catheterization to assess blood flow and angioplasty to open up the blocked heart artery and restore blood flow.