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Heart Disease Health Center

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At-Home Genetic Tests: Little Benefit, Little Risk

Study Shows Short-Term Impact on People Who Use at-Home Genetic Tests Is Small
By
WebMD Health News
Reviewed by Laura J. Martin, MD

Jan. 12, 2011 -- The marketing for controversial at-home genetics kits claim to empower users with the information they need to take steps to improve their health. But a new study suggests that, in the short term at least, the tests have little impact on behavior.

Known as direct-to-consumer genetic tests, the kits claim to provide consumers with actionable information about their risk for disease from a simple saliva sample mailed to the labs of the companies that sell them.

But the tests have come under fire from federal officials and were the subject of a congressional hearing last summer following the release of a Government Accountability Office report concluding that they often provide misleading information to consumers.

Impact of at-Home Genetics Test

The new study, which appears in the New England Journal of Medicine, does not directly address the clinical usefulness of the direct-to-consumer genetics tests. Rather, researchers wanted to know how the people who used them processed and acted on the information the tests provided.

The study included just over 2,000 people followed for three months after taking the direct-to-consumer test Health Compass, sold by the California-based company Navigenics.

A year’s subscription to the testing service costs about a thousand dollars, but the study participants received the subscription at a discounted rate.

The study measured anxiety levels and test-related actions among the participants after they learned the results of their DNA screening.

A major concern is that the tests will increase health-related anxiety among the people who use them, study researcher Cinnamon S. Bloss, PhD, tells WebMD.

Bloss is an assistant professor of the Scripps Translational Science Institute in La Jolla, Calif.

Nine out of 10 study participants reported no result-related stress three months after having the test, and there was little evidence of an increase in doctor-provided screening.

While about half of the participants said they planned to have medically delivered screening tests with greater frequency due to the DNA findings, Bloss says there was no evidence that they had done so.

Participants Didn’t Change Lifestyle

There was also little evidence that the people in the study made healthier lifestyle choices, such as exercising more and eating better, after learning their DNA results.

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