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Heart Disease Health Center

Some Men May Inherit a Higher Risk of Heart Disease From Dad

Study Shows Certain Genes Carried on the 'Male’ Chromosome May Increase Heart Disease Risk by 50%
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Finding May Explain Geographic Differences in Heart Disease

The lineage is more commonly found in northern European countries, like Denmark, Norway, and Sweden, and it becomes less frequent in southern countries including Spain, France, and Italy.

“You see kind of a gradient in Europe between the North and the South,” Bloomer says. “Many more people in the North have this group than in [the] South, and you have many more people getting coronary artery disease in the North of Europe than in the South.”

Beyond the association between heart disease and haplogroup, researchers went one step further. They looked to see if the activity of certain blood cells was different between ancestral groups. They found that genes related to the development of atherosclerosis -- hardening of the arteries -- were more active in men who belonged to haplogroup I. There were other key differences related to inflammation and immune function.

“The sex chromosomes matter in terms of disease,” says Virginia M. Miller, PhD, a professor of physiology and surgery at the Mayo Clinic in Rochester, Minn.

Miller, who studies sex differences in heart disease, wrote a commentary on the new findings, but she was not involved in the research.

For Men, Father’s Heart Disease History May Be an Underappreciated Risk

She says the new findings mean that family history may be a stronger predictor of heart disease risk for men than for women.

“You may have a family history, but this paper says it matters if it’s from your father’s side and you’re a man,” she says.

Some heart disease risk calculators, like the widely used Framingham Risk Score, don’t account for family history or whether it comes from the mother’s or father’s side, she says. If further research confirms the findings of this study, Miller thinks they will probably need adjusting.

“We need to broaden our scope in terms of what is the individual risk and really personalize it for people in terms of managing their own health,” she says.

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