Resveratrol is a member of a group of plant compounds called polyphenols. These compounds are thought to have antioxidant properties, protecting the body against the kind of damage linked to increased risk for conditions such as cancer and heart disease. Resveratrol is found in the skin of red grapes, but other sources include peanuts and berries.
Because resveratrol is thought to have so many health benefits, it's not surprising that a number of manufacturers have tried to capitalize by selling resveratrol supplements. Most resveratrol capsules sold in the U.S. contain extracts from the Japanese and Chinese knotweed plant Polygonum cuspidatum. Other resveratrol supplements are made from red wine or red grape extracts.
When Ramona Richman's older sister was diagnosed with high cholesterol, Richman wasn't worried about her own risk. The San Francisco Bay Area stay-at-home mom had her weight under control and assumed that her diet was healthy. So when her doctor broke the news that she, too, had high cholesterol, she was shocked. Her reading of 269 mg/dL was well over the desirable level of less than 200 mg/dL. "My sister had high cholesterol and went on medication, so I imagine that it's a genetic thing," Richman,...
Ads touting resveratrol supplements on the Internet promise purchasers everything from weight loss to a healthier, longer life. The question is, do resveratrol supplements really deliver on those promises, or are they nothing more than marketing hype?
Benefits of Resveratrol
Resveratrol has gained a lot of attention for its reported antiaging and disease-combating benefits. Early research, mostly done in test tubes and in animals, suggests that resveratrol might help protect the body against a number of diseases, including:
Heart disease. Resveratrol helps reduce inflammation, prevents the oxidation of LDL "bad" cholesterol, and makes it more difficult for platelets to stick together and form the clots that can lead to a heart attack.
Cancer. Resveratrol is thought to limit the spread of cancer cells and trigger the process of cancer cell death (apoptosis).
Alzheimer's disease. Resveratrol may protect nerve cells from damage and the buildup of plaque that can lead to Alzheimer's.
Diabetes. Resveratrol helps prevent insulin resistance, a condition in which the body becomes less sensitive to the effects of the blood sugar-lowering hormone, insulin. Insulin resistance is a precursor to diabetes.
Rodent studies suggest that resveratrol might even help against some of the effects of an unhealthy lifestyle and lead to increased longevity. Resveratrol-treated mice fed a high-calorie diet lived longer than similarly fed mice not given resveratrol. Resveratrol protected mice fed a high-calorie diet from obesity-related health problems by mimicking the effects of caloric restriction.
Resveratrol has also been linked to prevention of age-related problems such as heart disease and insulin resistance. Researchers believe that resveratrol activates the SIRT1 gene, a biological mechanism that seems to protect the body against the harmful effects of obesity and the diseases of aging.