Skip to content

Heart Disease Health Center

Font Size

Congenital Heart Defects: Prostaglandins and Prostaglandin Inhibitors - Topic Overview

Normally, a blood vessel needed only for fetal blood circulation (called the ductus arteriosus) closes off at birth. During fetal development, this blood vessel is kept open by a naturally occurring substance in the fetus's body called prostaglandin. At birth, fetal production of prostaglandin decreases and the ductus arteriosus closes.

In some premature infants, this blood vessel does not close. This is a condition called a patent (open) ductus arteriosus. These premature infants are given a prostaglandin inhibitor, a medicine to stimulate the closure of this blood vessel.

Recommended Related to Heart Disease

Thriving After 2 Heart Attacks

I had my first heart attack 26 years ago, when I was 52. I was very active then, sometimes jogging and often walking long distances. But I was also on the congressional staff in Washington, and the day leading up to the attack was even more hectic than usual. My boss was introducing major legislation, and I had crafted an important floor speech. I didn’t have time for regular meals and ate a huge cheeseburger for dinner, then smoked three or four cigarettes. It happened about 3 in the morning...

Read the Thriving After 2 Heart Attacks article > >

When an infant has certain other congenital heart defects, a medicine (a form of prostaglandin) is often given by vein to keep the ductus arteriosus open. Keeping this blood vessel open allows the blood to continue circulating until surgery or another procedure can be done to correct the related defect and allow normal blood flow.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Medical Reference from Healthwise

    Last Updated: March 12, 2014
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
    1
    Next Article:

    Congenital Heart Defects: Prostaglandins and Prostaglandin Inhibitors Topics

    Today on WebMD

    x-ray of human heart
    A visual guide.
    atrial fibrillation
    Symptoms and causes.
     
    heart rate graph
    10 things to never do.
    heart rate
    Get the facts.
     
    empty football helmet
    Article
    red wine
    Video
     
    eating blueberries
    Article
    Simple Steps to Lower Cholesterol
    Slideshow
     
    Inside A Heart Attack
    SLIDESHOW
    Omega 3 Sources
    SLIDESHOW
     
    Salt Shockers
    SLIDESHOW
    lowering blood pressure
    SLIDESHOW