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Now Playing: Predicting Transplant Rejection
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Reviewed By: Louise Chang,
SOURCES: 2007 Medical Reference from Medstar Television. Rakesh Sindhi, MD, Pediatric Transplant Surgeon, Children's Hospital of Pittsburgh, Pittsburgh, PA.
© 1999-2011 Medstar Television
Adelynn Rosner might have a future as a transplant surgeon… budding skills combined with personal experience.
Around Adelynn's fourth week after birth, she was still very jaundiced, so we went to the doctor, and um, they ran some blood tests and found out her bilirubin was very high.
Adelynn had a condition that was damaging her liver.
Fortunately, she did very well for several months, and was able to gain some weight and become much stronger by the time she needed her transplant.
Anti-rejection medicines are part of the equation after transplant to keep patients healthy, but doctors are still trying to find the right balance.
Where the drugs fail, they fail either because we're over-doing it, or we're under-doing it.
Resulting in rejection, if too little medicine is used, or cancer, if the dose is too high. To decipher this puzzle, transplant researchers at the Children's Hospital of Pittsburgh are poring over genetic clues.
We're trying to establish fingerprints, so-called genomic fingerprints, that will tell us that this person is going to be at risk for rejection.
They're focusing on so-called polymorphisms, or mistakes in DNA code.
We can measure up to about, or characterize up to about a half-a-million of the 12 million known mutations, and we try to characterize them not just in children, but in the parents.
And by sifting through these clues, they hope to understand which genes cause problems. Ultimately helping doctors personalize the medicine
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