Skip to content

    Heartburn/GERD Health Center

    Select An Article

    Prescription Drugs for Heartburn and Reflux

    Font Size
    A
    A
    A

    Frequent heartburn or gastroesophageal reflux disease (GERD) that occurs more than twice a week usually responds best to heartburn medicine that you take daily rather than just when you feel the heartburn. Most of the over-the-counter treatments, are not meant to be taken daily for a long time. Check in with your doctor to see if you need a prescription medicine for your heartburn.

    Histamine-2 (H2) Blockers for Heartburn and Reflux

    In prescription form (usually higher doses than the over-the-counter versions), H2 blockers can generally relieve heartburn and treat reflux, especially if you’ve never had treatment before. These drugs are particularly useful at alleviating heartburn, but may not be as good for treating esophagitis (inflammation that occurs in the esophagus) that is the result of GERD.

    Histamine stimulates acid production, especially after meals, so H2 blockers are best taken 30 minutes before meals. They can also be taken at bedtime to suppress nighttime production of acid. Examples of prescription H2 blockers:

    Side effects can include headache, abdominal pain, diarrhea, nausea, gas, sore throat, runny nose, and dizziness.

    Proton Pump Inhibitors (PPIs) for Heartburn and Reflux

    Depending on the source of your heartburn or reflux, your doctor can prescribe drugs that block acid production more effectively and for a longer period of time than the H2 blockers, namely the family of medications doctors call proton pump inhibitors. PPIs are best taken an hour before meals. They include:

    Most doctors do not believe that one drug is significantly more effective than the others in managing GERD. These medications are also good for protecting the esophagus from acid so that esophageal inflammation can heal.

    Side effects can include headache, diarrhea, abdominal pain, bloating, constipation, nausea, and gas.

    Promotility Agents for Heartburn and Reflux

    Promotility agents work by stimulating the muscles of the gastrointestinal tract, which may help prevent acids from staying in the stomach too long, and strengthening the lower esophageal sphincter, reducing reflux into the esophagus. Reglan is a promotility agent occasionally used to treat heartburn associated with GERD. The side effects of Reglan can be serious and may include drowsiness, fatigue, diarrhea, restlessness, and movement problems.

    Another promotility agent, Propulsid, was removed from the market in 2000, because it caused serious heart arrhythmias (abnormal heartbeats) in some people.

    WebMD Medical Reference

    Reviewed by Jennifer Robinson, MD on August 26, 2014
    Next Article:

    Today on WebMD

    Woman eating pizza
    How it starts, and how to stop it.
    man with indigestion
    Get lifestyle and diet tips.
     
    woman shopping for heartburn relief
    Medication options.
    man with heartburn
    Symptoms of both.
     
    digestive health
    Slideshow
    Heartburn or Heart Attack
    Article
     
    heartburn
    Article
    stomach acid rising
    Article
     
    Woman eating pizza
    Slideshow
    digestive myths
    Slideshow
     
    Extreme Eats
    Slideshow
    Bowl of pasta and peppers
    Slideshow