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Acid Reflux Drugs May Up Fractures

Osteoporosis Fractures May Be More Common in People Who Use Proton Pump Inhibitors for at Least 7 Years

Drugmakers Respond continued...

The drug company AstraZeneca makes Nexium. "AstraZeneca does not agree with the conclusion of the CMAJ study," states AstraZeneca spokeswoman Corey Windett in an email to WebMD. She says Nexium's safety and efficacy have been "consistently demonstrated." Windett says AstraZeneca also notes the study's limits and agrees with the editorialists that further research is needed and that patients and doctors should "weigh the proven benefits of these medications against any potential risks." Patients should talk to their doctors if they have concerns about bone health while taking Nexium or any other PPI, says Windett.

Judee Shuler, senior director of corporate communications for Eisai Inc., which makes Aciphex, states that the Canadian results "warrant further study, as these fractures are important medical issues that can occur for a variety of reasons. Our clinical trial data have not shown an increased risk of osteoporosis-related fractures in patients taking [Aciphex] tablets, nor have our post-marketing data suggested such an association, but we will continue to monitor our adverse event database."

The other PPI drugmakers didn't respond before deadline.

WebMD also contacted the Pharmaceutical Research and Manufacturers of America (PhRMA), which declined to comment on the study.

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