Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Hepatitis Health Center

Font Size

Experimental Hepatitis C Drug 'Promising'

Early Findings Show Good Response in Hard-to-Treat Patients
WebMD Health News

Oct. 27, 2003 -- Roughly half of all patients infected with hepatitis C virus can be cured. And now, an experimental drug is showing promise for the other half who don't respond to first-line hepatitis C drugs.

A California-based pharmaceutical company hopes its experimental drug will become the first hepatitis C drug to win approval for treatment of people who don't respond to initial treatment.

In a study sponsored by manufacturer SciClone Pharmaceuticals, 61% of people who had not responded to initial treatment improved with the experimental hepatitis C drug Zadaxin when combined with standard first-line hepatitis C drugs pegylated interferon and ribavirin.

The interim report on the ongoing pilot study involved just 23 patients treated for just 12 weeks, but a company spokesman calls the findings promising. The findings were reported at the annual meeting of the American Association for the Study of Liver Diseases (AASLD) in Boston.

At week 12, 10 of 16 study participants showed evidence that the amount of hepatitis C virus in their blood was falling -- called a virologic response. And nine of the 16 had a normal liver enzyme test.

"The fact that we have seen these early responses is certainly no guarantee that we will see sustained responses in these patients," SciClone vice president for medical affairs Eduardo Martins, MD, PhD, tells WebMD.

But he adds that previous research has suggested that when things look good early on, they are more likely to continue on that path. "We know that early virologic responses are very indicative of sustained responses in previously untreated patients."

More Ongoing Research

The company hopes to enroll 50 people in the ongoing trial of the three hepatitis C drugs. It is also conducting larger phase III trials of Zadaxin and pegylated interferon without ribavirin in patients who failed to respond to prior treatment. Patients in all of the studies will be treated for one year and will be observed for six months after that.

Hepatitis C treatment expert Howard J. Worman, MD, called the findings on the triple hepatitis C drug regimen "extremely preliminary," and he questioned the relevance of using early virologic response as a marker of success in this group of patients.

Today on WebMD

Hepatitus C virus
Types, symptoms and treatments.
liver illustration
Myths and facts about this essential organ.
woman eating apple
What you need to know.
doctor and patient
What causes it?
Hepatitis C Treatment
Syringes and graph illustration
liver illustration
passport, pills and vaccine
Scientist looking in microscope
Fatty Liver Disease
Digestive Diseases Liver Transplantation
Picture Of The Liver
Image Collection