Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

HIV & AIDS Health Center

Select An Article

Expanding HIV and AIDS Drug Options

Font Size

HIV Drugs continued...

Non-nucleoside RT inhibitors (NNRTIs) bind to the RT protein. This disables it, keeping HIV from making copies of itself.

The FDA has approved these NNRTIs:

Efavirenz (Sustiva)
Nevirapine (Viramune)
Delavirdine (Rescriptor)
Etravirine (Intelence)
Edurant (rilpivirine)

The FDA also approved two one-pill, once-a-day products to treat HIV. Atripla combines three different RT inhibitors (efavirenz + tenovir DF + emtricitabine). And Complera is a combination of Truvada (which combines the nucleoside reverse transcriptase inhibitors Emtriva and Viread) and the non-nucleoside reverse transcriptase inhibitor Edurant.

2. Protease inhibitors (PI) interfere with an enzyme that HIV uses to create infectious viral particles.

The FDA has approved these protease inhibitors:

Brand NameGeneric NameAbbreviation
Kaletralopinavir + ritonavirLPV

Taking Invirase with Norvir has been linked to a potentially serious drug interaction causing an abnormal heart rhythm. Your doctor may recommend heart monitoring. Also, the FDA says that taking the hepatitis C drug Victrelis (boceprevir) and ritonavir (when also taking atazanavir, lopinavir, or darunavir) can potentially reduce the effectiveness of these drugs. Tybost (cobicistat) is a drug that helps protease inhibitors work better.

3. Fusion inhibitors help block HIV's entry into healthy cells. At this time, Fuzeon (enfuvirtide), ENF, is the only one the FDA has approved.

4. Entry Inhibitors also help block HIV's entry into healthy cells. Currently, maraviroc (Selzentry) is the only FDA-approved drug, but others are in late stage clinical trials.

5. Integrase inhibitors block insertion of viral DNA into the host cell DNA. Currently, Isentress (raltegravir), Vitekta (elvitegravir), and Tivicay (dolutegravir) are the only FDA-approved drugs, but others are in clinical trials. Dolutegravir is part of a combination pill called Triumeg, which also includes abacavir and lamivudine.

How to Take HIV Drugs

There are many types of HIV drugs. Your doctor will provide you with specific directions for the medications you take. However, remember these important points:

  • Take all your HIV medication exactly as directed. Never even miss one dose. If you don't take them as directed, you may develop resistant strains of HIV, and your medication may stop working.
  • Check with your pharmacist or doctor about whether or not you should take your medications on an empty stomach. Taking them the right way can reduce side effects.
  • Tell your pharmacist or doctor about any dietary supplements or other medications you take. Some can interact with your HIV medications.
Next Article:

Today on WebMD

How much do you know?
contemplative man
What to do now.
Should you be tested?
HIV under microscope
What does it mean?
HIV AIDS Screening
man opening condom wrapper
HIV AIDS Treatment
Discrimination Stigma
Treatment Side Effects
grilled chicken and vegetables
obese man standing on scale
cold sore