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    HIV Vaccines

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    About 40 million people are living with HIV (human immunodeficiency virus) or AIDS (acquired immunodeficiency syndrome). Each day, 14,000 more become infected. HIV drugs have vastly improved the quality of life for many of these people, but they don't yet provide a cure. That's why researchers are working so hard to develop an HIVvaccine.

    How Vaccines Work

    A vaccine is a medical product that prevents or controls a specific infection by stimulating the body's immune system. Over the years, researchers have developed vaccines for countless diseases, including typhoid, measles, influenza, and smallpox.

    Why an HIV Vaccine Doesn't Yet Exist

    As many as one out of five Americans think an HIV vaccine already does exist. But nothing could be further from the truth. Across the globe, researchers at universities, drug and biotech companies, and government agencies are working very hard to make an HIV vaccine a reality. More money has been spent on finding an HIV vaccine than on any other vaccine in history.

    Then, why has it taken so long to produce an HIV vaccine -- more than 20 years after discovery of the virus? In fact, developing vaccines is almost always a long process. It took 47 years, for example, to develop a polio vaccine. Developing an HIV vaccine is even more difficult. These are a few reasons why:

    • The HIV virus makes copies of itself very quickly.
    • Many types of HIV exist, and new types continue to arise.
    • HIV has developed clever ways of "outwitting" the immune system. Consequently, none of the people infected by HIV have ever completely cleared it from their bodies.
    • Scientists are still trying to understand the specific ways the immune system needs to respond to prevent HIV infection

    Types of HIV Vaccines Being Tested

    Two main types of HIV vaccines are currently being tested -- preventive and therapeutic.

    Preventive HIV vaccines:

    • Are tested in people who are HIV-negative
    • Train the immune system to "recognize" and fight off HIV before it can establish infection and make the person sick
    • May one day work with varying degrees of success -- by preventing infection in all, most, or some people; by blocking continued infection; or by delaying or preventing the development of AIDS
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