Circumcision May Reduce Risk of HIV Infection
Study Shows Procedure Prevented 7 of 10 Potential Infections
WebMD News Archive
July 26, 2005 (Rio de Janeiro, Brazil) -- Circumcision may protect against
infection with the virus that causes AIDS.
In a study of more than 3,000 young men, those who were circumcised were 65%
less likely to be infected with HIV compared with those who were not
"Circumcision prevented 6 to 7 out of 10 potential HIV infections,"
says researcher Bertran Auvert, MD, MPH, professor of public health at the
University of Versailles-Saint Quentin in France.
Circumcision was so effective at preventing HIV transmission that the trial
was stopped early so that all the young men in the study could be offered the
procedure, he tells WebMD.
The study included 3,128 uncircumcised young men aged 18 to 24 in a rural
area outside of Johannesburg, South Africa. The men were randomly assigned
either to undergo the procedure or remain uncircumcised. All the men were
By about 1 1/2 years later, 51 men who had not been circumcised had been
infected with HIV, compared with only 18 who had the procedure, the study
The findings were presented at a meeting of the International AIDS
Too Soon to Recommend Widespread Circumcision
Doctors have long noticed that circumcised men appeared to be at lower risk
of HIV infection. But this is the first time that the observation has been
confirmed in a well-designed study in which half the men got the procedure and
the other half didn't, according to researchers at the meeting.
"These are very exciting new data on the potential of male circumcision
to reduce the risk of HIV transmission," says Helene Gayle, MD, president
of the International AIDS Society and director for HIV, TB and Reproductive
Health at the Bill and Melinda Gates Foundation.
But until the findings are confirmed in other ongoing studies, "it would
be premature to recommend widespread circumcision for HIV prevention," she
Gayle also cautions that men who are circumcised should not develop a false
sense of security and use it as an excuse for unsafe sex or other risky
Auvert agrees that questions remain. For example, doctors don't yet know if
circumcision can help protect against male-to-male transmission of HIV or
whether the findings will hold up over the long term.
But if confirmed, the implications are enormous, he says.
"About 70% of uncircumcised young men will opt to undergo the procedure
if it is shown to reduce the risk of HIV transmission."
Last year, there were 5 million new HIV infections worldwide -- more than in
any other year.