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Nonprogressors and HIV resistant

A few people with HIV are described as nonprogressors. These people have HIV that does not progress to more severe symptoms or disease. Most nonprogressors:

  • Have lived with the infection for 10 to 15 years and remained healthy.
  • Do not have declining CD4+ cell counts.
  • Have a very low level of HIV in their blood.

A small number of people never become infected with HIV despite years of exposure to the virus. For example, they may have repeated, unprotected sex with an infected person. These people are said to be HIV-resistant.

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Studies are under way to determine why some people either do not become infected with HIV or, if they do, why they do not develop symptoms or lose CD4+ cells. Research has shown that:

  • Some people's CD4+ cells are relatively resistant to HIV. If HIV cannot attach itself to CD4+ cells, it cannot destroy them.
  • Some people's immune systems may be better able to destroy the virus.
  • Some strains of HIV may not be as harmful.
ByHealthwise Staff
Primary Medical ReviewerKathleen Romito, MD - Family Medicine
Specialist Medical ReviewerAdam Husney, MD - Family Medicine
Last RevisedDecember 9, 2010

WebMD Medical Reference from Healthwise

Last Updated: December 09, 2010
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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