Checking to make sure that the TB medicines are
not changing the effectiveness of the medicines used to treat the HIV
Continuing treatment for longer than 6 months. Treatment
may go on for up to 9 months for people with both TB and HIV infections,
especially for children.
Avoiding the once-a-week treatment program
when using isoniazid-rifapentine after the first 2 months of TB therapy.
Instead, the medicines should be taken every day or 3 times a
Avoiding the twice-a-week treatment program when using
isoniazid-rifampin or rifabutin for people whose CD4+ lymphocyte counts are
less than 100/µl (100 cells per microliter). Instead, the medicines should be
taken every day or 3 times a week.
Treatment of latent TB in people with HIV infection
Experts recommend one of the following treatments to cure a latent TB infection in people with HIV infection.
Nine months of daily treatment with the antibiotic
isoniazid can help latent TB from becoming active TB, which can spread to other people.1
Three months of weekly doses of the antibiotics isoniazid and rifapentine can be effective for treating latent TB in people with HIV who are not taking antiretroviral medicines.2 For this treatment, a health professional watches you take each dose of antibiotics, called directly observed therapy (DOT). Making sure that every dose of antibiotic is taken helps prevent the TB bacteria from getting resistant to the antibiotics.
Treatment of active TB in people with HIV infection
People who are infected with HIV take a combination of four medicines
daily for 2 months to treat active TB. This is followed by two medicines daily
for the next 4 months.1
Appropriate treatment should last for at least
6 months. Treatment may go on longer if tests show that TB-causing bacteria are
still present in
sputum or in other areas of the body.
All doses of the antibiotics must be taken. This may require
daily visits with a health professional to receive every dose of your
medicines. This is called
directly observed therapy (DOT), and it improves the
cure rate of TB treatment.3
use another medicine instead of rifampin, which can lower the effectiveness of
some medicines used to treat HIV infection.
In this article
This information is produced and provided by the National
Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National
Institute via the Internet web site at http://
.gov or call 1-800-4-CANCER.
WebMD Medical Reference from Healthwise
April 04, 2013
This information is not intended to replace the advice of a doctor.
Healthwise disclaims any liability for the decisions you make based on this