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Diethylstilbestrol (DES)

Diethylstilbestrol (DES) is a medicine that was prescribed in the United States between 1948 and 1971 to prevent miscarriage or premature delivery. It is no longer prescribed, because it was found to cause various medical problems in the children of the women who used it.

Daughters born to women who took DES while pregnant have a slightly higher risk for:

  • Abnormal cervical cells that cause an abnormal Pap test.
  • Cancer of the cervix or vagina.
  • Structural problems in their reproductive organs, such as a T-shaped uterus or a weakened cervix, which can cause infertility and a higher risk for preterm labor.

Sons born to women who took DES while pregnant have a slightly higher risk of abnormalities of the scrotum and decreased sperm counts.

By Healthwise Staff
Primary Medical Reviewer Sarah Marshall, MD - Family Medicine
Specialist Medical Reviewer Kirtly Jones, MD - Obstetrics and Gynecology
Current as of March 12, 2014

WebMD Medical Reference from Healthwise

Last Updated: March 12, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.