Lung transplant for chronic obstructive pulmonary disease (COPD)

Although uncommon, lung transplants are sometimes used in chronic obstructive pulmonary disease (COPD). During a lung transplant, you are given a lung from a donor who has recently died. A single-lung transplant (receiving one lung) is done more often than a double-lung transplant (receiving two lungs). Improvement in the ability to exercise is nearly as good in people who have a single-lung transplant as it is in those who have a double-lung transplant.

Lung transplant surgery has been found to help people with COPD for at least 3 to 4 years after surgery. The long-term benefit of lung transplant for people with COPD is not yet known.

The criteria for selecting people with COPD to have a lung transplant have not been firmly established. Lung transplant for people with COPD may be considered for those who:

• Have severe lung disease.
• Are younger than 65.
• Have stopped smoking.
• Have family and friends who will help and encourage them during and after the surgery.
• Do not currently have a drug or alcohol abuse problem.

Other considerations for lung transplant include the following:

• It can take a long time to find a donor whose blood and tissue types match yours.
• You will have to take medication for the rest of your life to prevent rejection of the new lung. Even then, there is a chance that rejection will occur.
• The medications you must take suppress your immune system, resulting in an increased risk of developing severe and life-threatening infections.

If you are interested in lung transplants, you may be referred to a transplant center, where you will undergo extensive physical and psychological testing to see whether you are a good candidate for a lung transplant. The testing includes exercise tests, lung function tests, heart function tests, numerous blood tests, psychological profiles, and other specialized testing. In addition, you need to demonstrate mental stability and the commitment necessary to follow up with the numerous medical demands after the transplant.

If you become a candidate for a transplant, you are placed on a waiting list. Depending on where the transplant center is located, the wait for a lung transplant can be anywhere from 1 year to over 2 years.