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Medications that can cause osteoporosis

Certain medications are known to cause bone loss, leading to osteoporosis. These include:

  • Oral or high-dose inhaled corticosteroids-such as prednisone and beclomethasone (QVAR)-used for more than 6 months to treat conditions such as asthma, arthritis, and lupus.
  • Thyroid replacement medication, if the dose is more than the body needs. This should be monitored by checking the level of thyroid-stimulating hormone (TSH) every year.
  • Medications used to treat seizures, such as phenytoin.
  • Medications used to treat endometriosis, such as leuprolide (Lupron Depot) and nafarelin acetate (Synarel).
  • Certain cancer treatments, including aromatase inhibitors used to treat breast cancer, such as anastrozole (Arimidex), letrozole (Femara), and exemestane (Aromasin).
  • Heparin, a blood thinner, if used for a long time.
  • Depo-Provera, a birth control medication given by injection, if used for a long time.
  • Anticonvulsant medications such as carbamazepine.
Author Robin Parks, MS
Editor Kathleen M. Ariss, MS
Associate Editor Denele Ivins
Associate Editor Pat Truman, MATC
Primary Medical Reviewer Joy Melnikow, MD, MPH
- Family Medicine
Specialist Medical Reviewer Carla J. Herman, MD, MPH
- Internal Medicine
Last Updated December 1, 2006

WebMD Medical Reference from Healthwise

Last Updated: December 01, 2006
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.