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Medicines that interact with alcohol

Many prescription and over-the-counter medicines interact with alcohol. For example, drinking while taking a diabetes medicine such as metformin (Glucophage) could result in very low blood sugar levels. Drinking while taking medicine for heartburn such as cimetidine (Tagamet) or ranitidine (Zantac) could result in a fast heartbeat.

Common medicines that interact with alcohol include:

  • Acetaminophen (such as Tylenol).
  • Antibiotics.
  • Antihistamines.
  • Tranquilizers.
  • Aspirin and other medicines to prevent clotting of blood (anticoagulants).
  • Some medicines to treat depression (antidepressants).
  • Medicines to treat diabetes (hypoglycemics).

If you are taking any over-the-counter or prescription medicine, ask your doctor or pharmacist whether you can safely drink alcohol.

Author Jeannette Curtis
Author Paul Lehnert
Editor Roya Camp
Editor Katy E. Magee, MA
Associate Editor Terrina Vail
Primary Medical Reviewer Adam Husney, MD
- Family Medicine
Specialist Medical Reviewer James R. McKay, PhD
- Psychology
Last Updated February 15, 2008

WebMD Medical Reference from Healthwise

Last Updated: February 15, 2008
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.