Plaque is a buildup of cholesterol, white blood cells, calcium, and other substances in the walls of arteries. Over time, plaque narrows the artery, and the artery hardens (atherosclerosis).
Plaque sometimes reduces blood flow to the heart muscle, which can cause angina symptoms, such as chest pain or pressure. Plaque in the large artery in the neck (carotid artery stenosis) may block blood flow to the brain and is a common cause of transient ischemic attack (sometimes called "mini-stroke") and stroke.
Plaques are covered with a fibrous cap, which may rupture if some trigger causes a surge in blood pressure or causes the artery to constrict. A person may have a heart attack or stroke if a plaque breaks open, creating a blood clot that completely blocks blood flow through the artery.
Primary Medical ReviewerE. Gregory Thompson, MD - Internal Medicine
Specialist Medical ReviewerKarin M. Lindholm, DO - Neurology
Current as ofAugust 13, 2014
WebMD Medical Reference from Healthwise