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Zollinger-Ellison Syndrome

Zollinger-Ellison syndrome is a rare condition in which a tumor called a gastrinoma forms in the pancreas or small intestine. The tumor releases a hormone called gastrin that causes production of excess stomach acid.

Almost all people who have Zollinger-Ellison syndrome get an ulcer at some point, usually in the small intestine (duodenal ulcer). Ulcers produced by this disease are more difficult to cure than ulcers from other causes.

In about half of the people with Zollinger-Ellison syndrome, the tumors (gastrinomas) are cancerous and can spread to the lymph nodes and liver.

The main treatment for Zollinger-Ellison syndrome is removal of the tumors and taking acid-suppressing medicine called proton pump inhibitors.

By Healthwise Staff
Primary Medical Reviewer E. Gregory Thompson, MD - Internal Medicine
Specialist Medical Reviewer Jerome B. Simon, MD, FRCPC, FACP - Gastroenterology
Current as of November 15, 2013

WebMD Medical Reference from Healthwise

Last Updated: November 15, 2013
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.