Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Hypertension/High Blood Pressure Health Center

Font Size

Combination Treatment for Hypertension

Having blood pressure problems? If one medicine can't lower your blood pressure, your doctor may try combination treatment for hypertension.

Studies show that many people get better control of blood pressure with combination treatment than with one drug.

Recommended Related to Hypertension

To Drink or Not to Drink: High Blood Pressure and Alcohol

Some research shows that drinking alcohol in moderation makes for a healthier heart. But is drinking risky or good for your blood pressure? Weigh the pros and cons to help you make the smart choice.

Read the To Drink or Not to Drink: High Blood Pressure and Alcohol article > >

There are many medications that are used in combination to help control high blood pressure. The goal is clear: control hypertension and you can lower your risk of heart disease.

When is combination treatment for high blood pressure necessary?

Combination treatment means another class of blood pressure medication is added to the first drug to increase effectiveness.

Many people with mild high blood pressure respond to one medication. It may take a few tries to find the most effective drug.

However, sometimes one drug cannot control high blood pressure. The doctor may increase the dose or change the medication, yet the blood pressure stays high. That's when a second drug may be added.

Sometimes, patients with higher blood pressure need combination treatment -- even initially -- to bring it to a normal range.

Combination treatment for hypertension is individualized. It gives the best possible control of blood pressure with the fewest side effects.

Also, combination treatment may cost less. There may be less frequent doctor visits as the drug combination effectively manages the hypertension.

What combinations of drugs are used to treat high blood pressure?

Different combinations of drugs in varying dosages are used to treat hypertension. Sometimes, using lower doses of one or more drugs in combination can minimize side effects.

Thiazide diuretics may be used alone to treat hypertension. Yet, low-dose diuretics are also used with medications such as beta-blockers.

When used in a drug combination, the diuretic has fewer side effects. It also boosts the blood-pressure-lowering effect of the other medication.

Diuretics are added to other blood pressure medications. For instance, if the person with high blood pressure also retains fluid, a diuretic may be added.

ACE inhibitors or angiotensin receptor blockers are often effective when combined with other classes of medications.

Sometimes, a beta-blocker is combined with an alpha-blocker. This may be useful for men who have hypertension and an enlarged prostate. The alpha-blocker may help both problems at the same time.

1 | 2 | 3

Today on WebMD

blood pressure
Symptoms, causes, and more.
Learn the causes.
Compressed heart
5 habits to change.
Mature man floating in pool, goggles on head
Exercises that help.
heart healthy living
Erectile Dysfunction Slideshow
Bernstein Hypertension Affects Cardiac Risk
Compressed heart
Heart Disease Overview Slideshow
thumbnail for lowering choloesterol slideshow
Heart Foods Slideshow
Low Blood Pressure