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Hypertension/High Blood Pressure Health Center

Gout Drug May Lower Blood Pressure

Study Shows Allopurinol Helps Fight Hypertension for People on a High-Sugar Diet
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Fructose, Uric Acid, and Blood Pressure

The study included 74 middle-age men whose average age was 51. All of the men ate 200 grams (800 calories) of fructose every day for two weeks in addition to their regular diets.

To put this in perspective, a recent national health survey suggests that added sugars account for about 400 calories consumed by the average American each day.

Almost all of the sugars and syrups used to sweeten processed foods contain roughly equal amounts of fructose and another sugar, glucose.

Table sugar is made up of about 50% fructose and 50% glucose, while high-fructose corn syrup is 55% fructose and 45% glucose.

All the men in the study ate the high-fructose diets, but half also took the gout drug.

After two weeks on the high-sugar diet, the men who took the drug showed significant declines in uric acid levels and no significant increase in blood pressure.

In contrast, men who did not take the drug had increases of about 6 points in systolic blood pressure (the top blood pressure number) and 3 points in diastolic blood pressure (the bottom blood pressure number).

American Heart Association Recommendations

While it is too soon to recommend taking uric acid-lowering drugs to lower blood pressure, it is clear that too much sugar in the diet can hurt the heart, Johnson says.

The American Heart Association reached the same conclusion in guidelines published last month.

The group recommends that:

  • Women eat no more than 25 grams (100 calories) of added sugar per day, which is equivalent to about six teaspoons. 
  • Men should eat no more than 37.5 grams (150 calories) of added sugar, which is equivalent to nine teaspoons. 
  • Foods high in added sugars should not take the place of foods that contain essential nutrients.

"Sugar has no nutritional value other than to provide calories," University of Vermont professor of nutrition Rachel K. Johnson, PhD, MPH, notes in a written statement.

She adds that soft drinks and other sugar-sweetened beverages are the No.1 source of added sugar in the typical American's diet.

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