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Humira

Humira may reduce symptoms of moderate to severe Crohn’s disease in people who have not responded to standard treatment or to Remicade. Humira may also help keep Crohn’s symptoms in remission.

How given: injection under the skin

Common side effects:

  • Redness, swelling, itching, pain, rash, or bruising at the injection site
  • Upper respiratory or sinus infections
  • Headache
  • Nausea

Other potential side effects: As with the other drugs in this class, Humira has the potential for serious side effects, including TB, sepsis, and other infections. There are also rare cases of people who have developed cancers such as lymphoma.

Remicade

Remicade may reduce symptoms of moderate to severe Crohn’s disease in people who have not responded to standard treatment. It may also help heal and reduce the number of fistulas. Fistulas are abnormal tunnels that connect from one part of an intestine to another, or from the intestine to the bladder, vagina, or skin. They often become infected and drain pus, mucus, or stool.

How given: intravenous (IV) injection

Common Side Effects:

  • Redness, swelling, itching, pain, rash, or bruising at the infusion site
  • Upper respiratory or sinus infections
  • Sore throat
  • Headache
  • Rash
  • Nausea
  • Coughing
  • Stomach pain

Other potential side effects: Likethe other drugs in this class, there is a potential for more serious side effects, such as TB and sepsis. And as with the other drugs in its class, there are also rare cases of people who have developed cancers such as lymphoma. 

Tysabri

Your doctor may recommend Tysabri if you have moderate to severe Crohn's disease with signs of inflammation when other treatments haven't worked or if you can't take them. Tysabri should not be taken in combination with other biologics or other drugs that block the immune system.

How given: intravenous (IV) injection

Common Side Effects:

  • Upper respiratory infections
  • Urinary tract infections
  • Headache
  • Depression
  • Tiredness
  • Diarrhea
  • Stomach pain
  • Rash

Other potential side effects: Tysabri increases the risk of a very rare but potentially fatal brain infection called progressive multifocal leukoencephalopathy (PML). Tysabri also can cause allergic reactions and liver damage.

Work Closely With Your Doctor

If your doctor prescribes biologics, they will closely monitor you to be sure the treatment works safely and effectively. So keep all appointments for lab work and doctor visits.

Let your doctor know about all prescription and over-the-counter drugs you take, as well as any supplements or natural remedies. Because some drugs can interact with other drugs, herbs, and supplements, it’s important not to start taking any new drug or treatment without first consulting your doctor.