Parasitic Worms Ease IBD
May Reduce Overactive Immune Response Behind Crohn's Disease, Ulcerative Colitis
Each dose contained about 2,500 live whipworm eggs, harvested at a USDA laboratory.
His findings, reported in the September issue of the American Journal of Gastroenterology, were originally presented before at an American Gastroenterological Association conference in 1999. The Iowa team is currently conducting two other studies, involving about 100 patients, in which half get the worm egg solution and the others get a placebo mixture. The patients don't know which liquid they receive. Worms for Future Treatment?
IBD is believed to be among the "autoimmune" disorders that includes lupus, multiple sclerosis, and psoriasis and may result from an overactive immune response, in which cells that normally attack invading disease and infection instead target healthy tissue. With IBD, the immune system may overreact to normal intestinal bacteria, causing inflammation and gradually eating away at the intestinal lining.
Summers says the worm eggs decrease this overactive immune response, possibly by secreting a substance.
"We know that people with certain colonized worms in their digestive tracts have a reduced immune response," he tells WebMD. "Therefore, we're hopeful that this treatment may someday prove useful for other autoimmune diseases."
In fact, Crohn's and ulcerative colitis are often treated with medications that suppress immune response (immunomodulators), such as AZA and Mexate. Other IBD drug treatments include antibiotics, corticosteroids such as Prednisone, or aminosalicylates such as Azulfidine and Dipentum.
More recently, some patients have been treated with "probiotics" -- bacteria given specifically to retain remission that appear to work as well as immune-suppressing drugs, says IBD expert Seymour Katz, MD, past president of the American College of Gastroenterology and clinical professor of medicine at New York University School of Medicine.
"So it's not that much of a galactic leap to say, 'Let's go one step further and introduce these worms to change the immunologic response of IBD patients," Katz tells WebMD. "This is certainly an intriguing concept that has merit, but the data is still very premature. And knowing the litigious nature of society, in addition to the fact that most people are repulsed by the thought of being given worms, there's a lot of baggage that needs to be overcome."