Crohn's disease is an ongoing (chronic) condition that may flare up throughout your life. It affects different people in different ways. Some people may have only mild symptoms. Others may have severe symptoms or complications that, in rare cases, may be life-threatening.
Although there are many theories about what causes Crohn's disease, none of them have been proven. There is a benefit, though, in understanding the possible causes of Crohn's disease and how they interact with one another. Doing so can help one better understand the symptoms, diagnosis, and treatment of Crohn's disease.
Scientists believe that Crohn's disease is caused by a combination of these factors:
Immune system problems
How might each of these factors...
Crohn's disease may be defined by the part of the digestive tract involved, such as the rectum and anus (perianal disease) or the area where the small intestine joins the large intestine (ileocecal disease). Some people may have features of both Crohn's disease and ulcerative colitis, the other major type of inflammatory bowel disease (IBD).
In long-term Crohn's disease, scar tissue may replace some of the inflamed or ulcerated intestines. This scar tissue can form blockages (bowel obstructions) or narrowed areas (strictures) that can prevent stool from passing through the intestines. Blockages in the intestines also can be caused by inflammation and swelling, which may improve with medicines. Sometimes blockages can only be treated with surgery.
If sores break through the wall of the intestines, abnormal connections or openings (fistulas) may form. Fistulas can form between two parts of the intestines, between the intestines and other organs (such as the bladder or vagina), or between the intestines and the skin. In rare cases, this can lead to infection of the abdominal wall.
Crohn's disease of the colon and rectum that has been present for 8 years or longer increases the risk of cancer. With regular screening, some cancers can be found early and treated successfully.
Most women who have Crohn's disease can have a normal pregnancy and deliver a healthy baby. The best idea is to wait until the disease is in remission before becoming pregnant. Women who become pregnant when their disease is under control are more likely to avoid flare-ups during pregnancy.
Some medicines used to treat the disease can be used during pregnancy. It's a good idea to talk with your doctor about which medicines are okay. But sometimes severe Crohn's disease can harm your baby more than medicines to keep it under control.
In this article
WebMD Medical Reference from Healthwise
November 14, 2014
This information is not intended to replace the advice of a doctor.
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