Skip to content

    Irritable Bowel Syndrome (IBS) Health Center

    Font Size

    Antibiotic May Aid Irritable Bowel

    Xifaxan Reduces Bloating, May Attack Main IBS Cause
    WebMD Health News
    Reviewed by Louise Chang, MD

    Oct. 16, 2006 -- Ten days' treatment with the antibiotic Xifaxan reduces symptoms of irritable bowel syndrome (IBS), a small clinical trial suggests.

    IBS is a condition of the intestinal tract that causes symptoms of bloating, gas, abdominal cramping, diarrhea, and constipation.

    Xifaxan, now approved for the treatment of travelers' diarrhea, kills bacteria living in the gut. Experts disagree over the cause of IBS. Some suspect the root cause to be overgrowth of gut bacteria.

    One of these experts is Mark Pimentel, MD, director of the gastrointestinal motility program at Cedars-Sinai Medical Center in Los Angeles. In prior studies, Pimentel used breath tests to show that about 80% of IBS patients may have serious bacterial fermentation going on in their gut.

    This led him to wonder what would happen if he used a powerful antibiotic to shift the balance between overgrowth of these theoretically harmful bacteria and normal bacteria living in the gut.

    So Pimentel and colleagues gave a 10-day course of Xifaxan or inactive placebo to 87 IBS patients. Seventy-two patients finished the study. As is common in IBS studies, those who got placebo felt a bit better. Those who got Xifaxan reported even more improvement -- especially less bloating.

    "Xifaxan was superior to placebo for control of IBS," Pimentel tells WebMD. "It suggests we are finally tackling a sustainable cause of IBS. If it is bacteria, we have changed the environment so that IBS is better on a semipermanent basis."

    The study, funded by Xifaxan maker Salix Pharmaceuticals, appears in the Oct. 17 issue of Annals of Internal Medicine. Pimentel is a consultant to Salix and has received speaking fees from the company. Cedars-Sinai Medical Center has a licensing agreement with Salix.

    Today on WebMD

    filling glass of water from faucet
    Prevention strategies to try.
    stomach ache
    From symptoms to treatments.
    Causes, symptoms, and treatments.
    worried mature woman
    Are they related?
    IBS Trigger Foods
    Supplements for IBS What Works
    IBS Symptoms Quiz
    digestive health
    gluten free diet
    digestive myths
    what causes diarrhea
    man with abdominal pain