Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Infertility & Reproduction Health Center

Font Size

Study Finds Fertility Treatment Not Linked to Most Birth Defects


Along with the medical records of babies conceived through ICSI, Wennerholm and colleagues studied records of babies conceived without fertility treatments, and those conceived through conventional in vitro fertilization. The ICSI babies included 200 sets of twins, and one set of triplets.

Among the ISCI babies, a birth defect was identified in 87 (7.6%). Of these, only eight were considered severe.

Though the findings of only small rates of minor birth defects associated with ICSI are encouraging, concern remains about another aspect of the treatment. Some research has found a missing gene in men with very low sperm counts, suggesting that men with fertility problems who are helped through ICSI may pass on the fertility problem to their sons.

"It's a very important question that we were not able to look at with the kind of study we conducted," Wennerholm tells WebMD. "It will require prospective studies and chromosome analysis, and there are ethical questions to consider."

Wennerholm tells WebMD that her group is continuing to study the health of children born as a result of ICSI. Approximately 600 such children from around the world who have reached the age of 5 will undergo psychological and physical tests of their mental development, brain function, vision and hearing, as well as family relationships. A preliminary report of the study is expected in the next year.

1 | 2

Today on WebMD

Four pregnant women standing in a row
How much do you know about conception?
Couple with surrogate mother
Which one is right for you?
couple lying in grass holding hands
Why Dad's health matters.
couple viewing positive pregnancy test
6 ways to improve your chances.
Which Treatment Is Right For You
Conception Myths
eddleman prepare your body pregnancy
Charting Your Fertility Cycle
Fertility Specialist
Understanding Fertility Symptoms
invitro fertilization

WebMD Special Sections