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Infertility & Reproduction Health Center

High-Protein Diet May Hurt Pregnancy Chances

But Findings Must Be Confirmed in Humans
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June 29, 2004 -- A study in mice suggests that following a high-protein diet may make it more difficult for women to get pregnant, but researchers say the findings must be confirmed in human studies.

In a presentation Monday to a European fertility group, researcher David Gardner, PhD, reported impaired implantation of a fertilized egg and disrupted embryo development in a group of female mice fed a diet containing 25% protein, when compared with mice who ate a diet that containing 14% protein -- an amount that is recommended by the American Heart Association and the National Cholesterol Education Program.

Eating a high-protein diet also seemed to disrupt a process known as imprinting, which controls which inherited genes become active.

"I certainly would not say that based on this research women should abandon high-protein diets to improve their chances of conceiving, but it is clear that human studies are needed," Gardner tells WebMD.

Ammonium and H19

Millions of women of childbearing age have turned to high-protein, low-carbohydrate eating plans like the Atkins diet to shed some pounds. These diets generally recommend dieters receive 30% to 50% of their total calories from protein.

But Gardner says the popularity of these diets was not the catalyst for his research. Instead, it was his own studies in mice, begun a decade ago, and other studies in cows showing that protein in the diet affects levels of the chemical ammonium in the female reproductive tract. Gardner showed that ammonium can inhibit imprinting of the gene H19, which has been shown to be important for growth, in mouse embryos.

In his latest study, Gardner and colleagues at the Colorado Center for Reproductive Medicine fed female mice diets containing either 25% or 14% protein for four weeks prior to mating. Following mating, embryos from mothers on both diets were examined for imprinting. They were later transferred to the wombs of mice eating normal diets to see the effects of the diet on embryo development prior to implantation.

The researchers found that 36% of the embryos from the mice on the high-protein diets developed normal imprinting, compared with 70% of the embryos from mice fed less protein.

The researchers also showed that just 65% of the embryos from the high-protein group developed into fetuses, compared with 81% of the embryos from the low-protein mice. Of those embryos that did develop into fetuses, the researchers found a significant delay in development in the high-protein group.

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