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Infertility & Reproduction Health Center

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Assisted Reproduction: No Birth Defect Risk

But Women Who Conceive With Help From Medical Science May Have More Pregnancy Complications
WebMD Health News
Reviewed by Louise Chang, MD

Nov. 2, 2005 -- Women who conceive with the help of assisted reproductive technology (ART) are more likely to have problems during their pregnancy, but their babies do not have a higher than normal risk for birth defects, a new study shows.

Researchers compared pregnancy outcomes among women who conceived with and without in vitro fertilization or other forms of assisted reproduction in a study published in the Nov. 1 issue of the journal Obstetrics and Gynecology.

Treatment for infertility was associated with a higher risk of complications prior to birth, including pregnancy-related high blood pressure and diabetes, placental problems, and even stillbirth.

Babies born as a result of assisted reproduction, however, were no more likely to have chromosomal abnormalities or birth defects than babies conceived without the help of medical science.

"Overall, this should be seen as a very reassuring finding," says researcher Tracy Shevell, MD, who specializes in treating high-risk pregnancies. "For the most part, the complications we found are easily identified and managed."

40,000 Babies a Year

In 2001, more than 40,000 babies -- roughly 1% of all births -- resulted from assisted reproductive technology (ART) procedures such as in vitro fertilization (IVF) and ovulation induction.

There has long been concern that children born via ART are at greater risk for complications that can follow them through life.

Past research has been mixed, but most earlier studies included twin and multiple-birth pregnancies, which have a higher risk of problems regardless of conception method.

In the study, researchers analyzed outcomes from roughly 36,000, single-birth pregnancies. Ninety-five percent were conceived without ART, 3.4% involved ovulation induction, and 1.5% involved IVF.

The women were followed closely throughout their pregnancies, and no evidence of an increase in low birth weight, chromosomal abnormalities, or birth defects was seen in babies born via ART.

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